Anti-convulsant assessment: preliminary evaluation of three medicinal plants growing in Bayelsa State

Alade GO1*, James KO2, Ajibesin KK1
1Department of Pharmacognosy & Herbal Medicine, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Nigeria.
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Nigeria.
*Correspondence: Gideon O. Alade; aladegideon@yahoo.com, gideonalade@ndu.edu.ng

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Abstract

Background: In Bayelsa, several plants are used in the treatment of convulsion, pain and mental illness; however, there is paucity of information on the neuropharmacological effects of these plants.
Objective: To evaluate the anticonvulsant effects of Sansevieria liberica Gérôme & Labroy, Artocarpus altilis (Parkinson) Fosberg and Allophylus africanus P.Beauv.
Materials and Methods: The whole plant of Sansevieria liberica Gérôme & Labroy (Asparagaceae) and the leaves of Artocarpus altilis (Parkinson) Fosberg (Moraceae), and Allophylus africanus P.Beauv. (Sapindaceae) were macerated in 50% ethanol. Using known procedure, anticonvulsant activity was assessed on the extracts at doses ranging from 200 to 1000 mg/kg based on their LD50 values. Normal saline and diazepam were used as control and reference drug, respectively. The phytochemical screening was also carried out on the extract of each plant.
Result: Sansevieria liberica showed the most significant anticonvulsant effect against Pentylenetetrazol induced seizures in a dose dependent manner (50 mg/kg, 100mg/kg and 200mg/kg), while Artocarpus altilis gave the least anticonvulsant activity, showed no statistical significance when compared with normal saline group and showed no pharmacological similarity with the standard group, diazepam. Saponins were detected in all the three plant extracts.
Conclusion: The ethanol extracts of the plant materials in this study suggest antiseizure potential.

Keywords: Epilepsy, Anticonvulsant, Medicinal plants, Seizures, Phytoconstituents.

Cite this article: Alade GO, James KO, Ajibesin KK. Anti-convulsant assessment: preliminary evaluation of three medicinal plants growing in Bayelsa State. Yen Med J. 2022;4(2):20–27

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