Gestational choriocarcinoma following a term pregnancy: A case report.

Wekere FCC1*, Kua PL1, Omunakwe H2
1Department of Obstetrics and Gynaecology, Rivers State University Teaching Hospital, Port Harcourt Rivers State, Nigeria.
2Department of Pathology, Rivers State University Teaching Hospital, Port Harcourt Rivers State, Nigeria.

*Correspondence: Dr. Felix C. C. Wekere; +2348035492898; fccwekere@yahoo.com

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Abstract

Background: Gestational choriocarcinoma co-existing with or following a term pregnancy is rare, highly metastatic and accounts for about one in one hundred and sixty thousand pregnancies. We report a rare case of gestational choriocarcinoma following term pregnancy, to highlight its presentation, diagnosis and management.
Case presentation: She was a 32-year-old Para-1 lady; rushed to accident and emergency unit of our hospital with complaints of recurrent severe vaginal bleeding, haemoptysis, and generalised body weakness three months following delivery of a healthy term baby. On examination at presentation, she was chronically ill looking, febrile, pale, anicteric, acyanosed, and moderately dehydrated with no pedal oedema. Pelvic ultrasonographic features were suggestive of gestational trophoblastic disease. Her Chest X-ray revealed metastasis to the lungs, and pre-treatment serum beta human chorionic gonadotrophin (β-hCG) level was 139,755 m IU/ml. Results of other investigations done were within normal range. She subsequently had suction evacuation, excision of vaginal and paraurethral lesions; received seven courses of combined chemotherapy (EMA /CO regimen) and serum β-hCG level reduced < 5 mIU/mL with complete remission of all metastatic deposits.
Conclusion: Gestational choriocarcinoma in high risk patient is curable with multiagent chemotherapy irrespective of its rapid metastatic nature and complications.

Key words: Gestational choriocarcinoma, EMA/CO Chemotherapy, Metastasis, β-HCG.

Cite this article: Wekere FCC, Kua PL, Omunakwe H. Gestational choriocarcinoma following a term pregnancy: A case report. Yen Med J. 2020;2(2):87–92.

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