Sero-susceptibility survey of rubella infection among women attending antenatal clinic at Federal Medical Centre, Umuahia, Abia State.

Okwara CE1*, Nduka EC1, Onuoha CO1, Azubuike KO1, Mbamba CC1
1Department of Obstetrics and Gynaecology, Federal Medical Centre, Umuahia, Abia State, Nigeria.
*Correspondence: Dr. Okwara, Ekene Cajethan; +234 803 296 0926;

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Background: Rubella is a common cause of childhood rash and fever. Acute rubella infection in the sero-negative pregnant woman in early pregnancy, is associated with risk of congenital rubella syndrome. Varying incidence rates of congenital rubella syndrome worldwide has been documented. Furthermore, vaccination programs exist in advanced countries unlike in developing world. The World health organization (WHO) recommends that countries determine their rubella prevalence and accordingly make plan for immunization against rubella.
Objective: To determine the seroprevalence of rubella infection among pregnant women attending antenatal clinic at Federal Medical Centre, Umuahia.
Materials and method: Two hundred and fifty-seven (257) pregnant women attending antenatal clinic of Federal Medical Centre, Umuahia who gave consent were consecutively recruited. Structured questionnaire was used to obtain required data from participants. Venous blood samples were taken from each woman. Rubella 1gG antibodies were determined in collected samples using fully automated ELECSYS 2010. Data analysis was done using SPSS version 20 statistical package.
Results: The average age of the participants in this study was 30.6 ± 4.9 years. Majority of the participants were married (98.4%), 83.7% in gainful employment and 71.2% had post-secondary education. All the subjects were Christians and none had previous rubella vaccination. Out of the 257 subjects, 237 had protective rubella 1gG antibody titre, hence sero-prevalence of 92%. This study did not show any association between rubella antibodies and socio-demographic characteristics.
Conclusion: This sero-prevalence rate suggests that one in ten pregnant women is susceptible, and the foetus at risk of congenital rubella syndrome.

Key words: Sero-susceptibility, Rubella, Pregnancy.

Cite this article: Okwara CE, Nduka EC, Onuoha CO, Azubuike KO, Mbamba CC. Sero-susceptibility survey of rubella infection among women attending antenatal clinic at Federal Medical Centre, Umuahia, Abia State. Yen Med J. 2020;2(2):65–72.


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